Electron Cryotomography of Bacterial Secretion Systems
نویسندگان
چکیده
منابع مشابه
Electron Cryotomography of Bacterial Cells
While much is already known about the basic metabolism of bacterial cells, many fundamental questions are still surprisingly unanswered, including for instance how they generate and maintain specific cell shapes, establish polarity, segregate their genomes, and divide. In order to understand these phenomena, imaging technologies are needed that bridge the resolution gap between fluorescence lig...
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15 Type IV secretion systems (T4SSs) are large macromolecular machines that translocate 16 protein and DNA and are involved in the pathogenesis of multiple human diseases. Here, 17 using electron cryotomography (ECT), we report the in situ structure of the Dot/Icm type 18 IVB secretion system (T4BSS) utilized by the human pathogen Legionella pneumophila. 19 This is the first structure of a type...
متن کاملCorrection to New Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography
This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
متن کاملLife with Bacterial Secretion Systems
Mysterious organelles that span the bacterial envelope have grabbed my heart throughout my life. It was not a coincidence that bacterial secretion systems, the pivotal machinery delivering virulent determinants into infected host cells, turned out to be my central interest after switching research subjects from the bacterial flagellum, which is a locomotive organelle. The virulent type III secr...
متن کاملNew Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography
Bacterial chemoreceptors cluster in highly ordered, cooperative, extended arrays with a conserved architecture, but the principles that govern array assembly remain unclear. Here we show images of cellular arrays as well as selected chemoreceptor complexes reconstituted in vitro that reveal new principles of array structure and assembly. First, in every case, receptors clustered in a trimers-of...
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ژورنال
عنوان ژورنال: Microbiology Spectrum
سال: 2019
ISSN: 2165-0497
DOI: 10.1128/microbiolspec.psib-0019-2018